A sponsor can apply for Designation status for Minor Use and Minor Species drugs prior to their approval or conditional approval. It makes the sponsor eligible for incentives to support the approval or conditional approval of the designated use.
The U.S. Food and Drug Administration is today announcing that five drug sponsors holding animal drug applications affected by Guidance For Industry (GFI) #213 have requested that FDA withdraw approval of a collective 19 applications for antimicrobials because the products are no longer manufactured or marketed.
Spider Bites in Pets: Black Widows
Written by Stacy Mantle
Thursday, 26 May 2011 00:03
It’s that time of year again and with all of the recent weather events we’ve had these days, it’s more important than ever to keep an eye out for spider bites on our pets.
Spider bites can be very difficult to spot and manage in pets. And unfortunately, pets are also very susceptible to getting bit. Cats in particular can obtain easy access to dark, quiet places that dogs often can’t manage. These are the very places that spiders love to hide.
Unfortunately, cats also have the most intense reactions to these bites. A single bite from a Black Widow can result in death. If you believe your cat (or dog) has been bitten, it’s important to have them treated immediately by a veterinarian.
That said, let’s move on to identifying symptoms of a Black Widow bite and why they are so toxic to our four-legged friends.
Identification of Black Widow Spiders Black Widow spiders are generally about an inch in diameter although they can be smaller or larger. The female (which is also the most poisonous and aggressive) of the species are a very glossy black and have a very distinctive red hourglass pattern on their stomachs as well as a bulbous black abdomen.
Black Widow Habits: Black Widows prefer to hide in dark crevices during the day.
Most active at night, black widows tend to spin very elaborate, “sticky” webs that appear almost overnight.
They appear most often in the warm climates of the Southwest, but have been found as far north as Canada and as far East as Florida. You will most often find them in dark garages, door frames and any place that is protected from predators and the elements.
While the Black Widow is not typically aggressive, it will bite to protect itself. The female is particularly given to a nasty bite while the males and juveniles are a bit more protective of their venom and generally are not as aggressive.
The Bite The toxin that is found in the Black Widow spider is actually a protein known as α-latrotoxin. This protein works with your pet’s nerve endings to create involuntary muscle contractions, a gradually increasing pain, and may cause elevated blood pressure.
What To Look For Neither you nor your pet may realize that they have even been bitten. Black Widow venom can cause very different responses in pets. Some have an almost immediate reaction with localized swelling, other animals don’t show any symptoms until several hours later when the protein reaches their lymph nodes. There may be no swelling or pain at the actual site of the bite. Its believed that the most severe pain will be realized one to three hours after a bite.
Look for the following symptoms in your dog:
Restlessness (your pet may have a difficult time getting comfortable)
Increased heart rate
Muscle rigidity (particularly in the abdomen)
Cats show far more severe signs including:
Antivenon: Antivenons are available for Black Widow bites, but are generally not administered due to the extremely high cost. Most vets are unable to keep an antivenon in stock due to a short shelf life. It is likely that if you choose to have this administered, a veterinarian will need to retrieve it from a human emergency facility.
Is this an emergency?
In Cats: Yes! If you suspect your pet has been bitten by a Black Widow, take your pet immediately to the emergency vet. The toxin in Black Widows is particularly deadly to our feline friends and requires immediate treatment.
In Dogs: Contact your vet immediately and discuss options for treatment. If your vet is familiar with your pet, they may ask to see it immediately or they may recommend that you pack the area in ice to reduce inflammation. Only your vet will be able to recommend a course of action.
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